Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376738 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Synthetic investigations of ustiloxin natural products are described. The first total synthesis of ustiloxin F was completed in 15 steps via ethynyl aziridine ring-opening by a phenol derivative. The results of biological tests of synthetic ustiloxins D and F, and two analogs, O-Me-ustiloxin D and 6-Ile-ustiloxin, demonstrated that the free hydroxyl group ortho to the ether linkage is critical for activity and variations at the Val/Ala site produce changes in the biological activity suggesting the need for further perturbations at this site to more extensively study the tubulin binding.
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Related Topics
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Organic Chemistry
Authors
Pixu Li, Cory D. Evans, Erin M. Forbeck, Haengsoon Park, Ruoli Bai, Ernest Hamel, M.M. Joullié,