| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376741 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A novel series of 2-amino-4-(7-azaindol-3-yl)pyrimidines was discovered as cyclin dependent kinase 1 (CDK1) inhibitors. The core structure was synthesized via Pd(II) catalyzed coupling reaction. A number of analogues showed good potency for CDK1 and exhibited cellular antiproliferation activity. The structure-activity relationship is described.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shenlin Huang, Ronghua Li, Peter J. Connolly, Stuart Emanuel, Steven A. Middleton,