Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376743 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
New bis-aromatic and heterocyclic trisulfide derivatives 5, 7–10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4) to evaluate their anti-tumor activities. Five compounds 5–7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.
Graphical abstractNew bis-aromatic and heterocyclic trisulfide derivatives 5, 7–10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4) to evaluate their anti-tumor activities. Five compounds 5–7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.Figure optionsDownload full-size imageDownload as PowerPoint slide