| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376744 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A functional screening highlighted a series of spiro-piperidines as 5-HT2B receptor antagonists. Preliminary structure–activity relationship has been explored driving to potent antagonists (IC50 = 1 nM) and indicating directions for further explorations.
Graphical abstractThe synthesis of the compound 45 (IC50 = 1.8 nM) and its analogs is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hugues Bienaymé, Laurent Chêne, Serge Grisoni, Antonio Grondin, El-Bachir Kaloun, Stéphane Poigny, Houcine Rahali, Eric Tam,