Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376745 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Herein we report the structure–activity relationships (SARs) of this novel class of dihydropyrone-containing compounds that show potent inhibitory activities against the HCV RNA polymerase in biochemical assays.
Graphical abstractThe discovery and SAR of a novel series of HCV polymerase inhibitors are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hui Li, John Tatlock, Angelica Linton, Javier Gonzalez, Allen Borchardt, Peter Dragovich, Tanya Jewell, Tom Prins, Ru Zhou, Julie Blazel, Hans Parge, Robert Love, Michael Hickey, Chau Doan, Stephanie Shi, Rohit Duggal, Cristina Lewis, Shella Fuhrman,