| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376749 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
New bis-pyridinium oxime reactivators connected with CH2O(CH2)nOCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N′-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.
Graphical abstractNew bis-pyridinium oxime reactivators connected with CH2O(CH2)nOCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent.Figure optionsDownload full-size imageDownload as PowerPoint slide
