| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376753 | Bioorganic & Medicinal Chemistry Letters | 2006 | 7 Pages |
Abstract
A strategy of systematically targeting more rigid analogues of the known MCH R1 receptor antagonist, SB-568849, serendipitously uncovered a binding mode accessible to N-aryl-phthalimide ligands. Optimisation to improve the stability of this compound class led to the discovery of novel N-aryl-quinazolinones, benzotriazinones and thienopyrimidinones as selective ligands with good affinity for human melanin-concentrating hormone receptor 1.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David R. Witty, John Bateson, Guillaume J. Hervieu, Kamal Al-Barazanji, Phillip Jeffrey, Dieter Hamprecht, Andrea Haynes, Christopher N. Johnson, Alison I. Muir, Peter J. O’Hanlon, Geoffrey Stemp, Alex J. Stevens, Kevin Thewlis, Kim Y. Winborn,