| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376757 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
A series of 4-(substituted)-3,4-dihydropyrimidinone derivatives have been synthesized by heating 1,3 dicarbonyl compounds, urea, and aromatic aldehydes in acetic acid under microwave irradiation conditions. The cardiovascular effects of 3,4-dihydropyrimidinones were studied on isolated perfused frog heart at different dose levels and compared with the activity of digoxin. The interaction of 3,4-dihydropyrimidinones with β-blocker and calcium channel blocker was also investigated. Compound 4d emerged as the most interesting compound in this series with potential cardiotonic activity.
Graphical abstractA series of 4-(substituted)-3,4-dihydropyrimidinone derivatives have been synthesized and evaluated for cardiovascular effects at different dose levels. The interaction with β-blocker and calcium channel blocker was also investigated. Entry 4d emerged as the most interesting compound in this series.Figure optionsDownload full-size imageDownload as PowerPoint slide
