| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376759 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
The structure–activity and structure–property relationships of anilinoquinazoline inhibitors of EGFR were investigated. Strategies to lower volume of distribution and shorten half-life through structure and pKa modulation are discussed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peter Ballard, Robert H. Bradbury, Craig S. Harris, Laurent F.A. Hennequin, Mark Hickinson, Jason G. Kettle, Jane Kendrew, Teresa Klinowska, Donald J. Ogilvie, Stuart E. Pearson, Emma J. Williams, Ingrid Wilson,