| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376760 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A focused library of variously substituted 9-aminoacridine compounds was screened for bioactivity against accumulation of the infectious prion protein isoform, denoted PrPSc, in a cell model of prion replication. The efficacy of compounds against PrPSc accumulation was influenced by both substituents of the distal tertiary amine and acridine heterocycle, while cellular cytotoxicity was encoded in the acridine heterocycle substituents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Barnaby C.H. May, Juanita Witkop, John Sherrill, Marc O. Anderson, Peter B. Madrid, Julie A. Zorn, Stanley B. Prusiner, Fred E. Cohen, R. Kiplin Guy,