Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376762 | Bioorganic & Medicinal Chemistry Letters | 2006 | 9 Pages |
Abstract
The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited considerable binding affinity (Ki = 1 nM) and functional activity at MCH-R1, acceptable CYP2D6 inhibition, and good rat brain exposure.
Graphical abstractThe design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited considerable binding affinity (Ki = 1 nM) and functional activity at MCH-R1, acceptable CYP2D6 inhibition, and good rat brain exposure.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sarah Hudson, Mehrak Kiankarimi, Martin W. Rowbottom, Troy D. Vickers, Dongpei Wu, Joseph Pontillo, Brett Ching, Wesley Dwight, Val S. Goodfellow, David Schwarz, Christopher E. Heise, Ajay Madan, Jenny Wen, William Ban, Hua Wang, Warren S. Wade,