| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376763 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Guanidine-based peptide nucleic acid (GPNA) monomers and oligomers containing all four natural (adenine (A), cytosine (C), guanine (G), and thymine (T)) and two unnatural (2-thiouracil (sU) and 2,6-diaminopurine (D)) nucleobases have been synthesized. Thermal denaturation study showed that GPNA oligomers containing alternate D-backbone configuration bind sequence-specifically to DNA and, when incubated with mammalian cells, localized specifically to the endoplasmic reticulum (ER).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peng Zhou, Anca Dragulescu-Andrasi, Birendra Bhattacharya, Heather O’Keefe, Paolo Vatta, Jens J. Hyldig-Nielsen, Danith H. Ly,