| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376765 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.
Graphical abstractA series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhao-Kui Wan, Jinbo Lee, Weixin Xu, David V. Erbe, Diane Joseph-McCarthy, Bruce C. Follows, Yan-Ling Zhang,