| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376769 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17β-HSD II for the treatment of osteoporosis. Biochemical data for several compounds are given. Compound 42 was selected as the lead candidate.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jill Wood, Cedo M. Bagi, Christiana Akuche, Antonietta Bacchiocchi, Jeremy Baryza, Marie-Luise Blue, Catherine Brennan, Ann-Marie Campbell, Soongyu Choi, James H. Cook, Patricia Conrad, Brian R. Dixon, Paul P. Ehrlich, Todd Gane, David Gunn, Ted Joe,