Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376777 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
A novel structural class of p38α MAP kinase inhibitors has been identified via iterative SAR studies of a focused deck screen hit. Optimization of the lead series generated 6e, BMS-640994, a potent and selective p38α inhibitor that is orally efficacious in rodent models of acute and chronic inflammation.
Graphical abstractSAR studies leading to the identification of the orally active anti-inflammatory agent BMS-640994 (6e) are disclosed.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
John Hynes Jr., Hong Wu, Sidney Pitt, Ding Ren Shen, Rosemary Zhang, Gary L. Schieven, Kathleen M. Gillooly, David J. Shuster, Tracy L. Taylor, XiaoXia Yang, Kim W. McIntyre, Murray McKinnon, Hongjian Zhang, Punit H. Marathe, Arthur M. Doweyko,