Article ID Journal Published Year Pages File Type
1376777 Bioorganic & Medicinal Chemistry Letters 2008 6 Pages PDF
Abstract

A novel structural class of p38α MAP kinase inhibitors has been identified via iterative SAR studies of a focused deck screen hit. Optimization of the lead series generated 6e, BMS-640994, a potent and selective p38α inhibitor that is orally efficacious in rodent models of acute and chronic inflammation.

Graphical abstractSAR studies leading to the identification of the orally active anti-inflammatory agent BMS-640994 (6e) are disclosed.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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