Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376779 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
We have identified a novel series of potent p38 MAP kinase inhibitors through structure-based design which due to their extended molecular architecture bind, in addition to the ATP site, to an allosteric pocket. In vitro ADME and in vivo PK studies show these compounds to have drug-like characteristics which could result in the development of an oral treatment for inflammatory conditions.
Graphical abstractThe design and synthesis of novel α-ketoamide-based p38 inhibitors is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Antonio Garrido Montalban, Erik Boman, Chau-Dung Chang, Susana Conde Ceide, Russell Dahl, David Dalesandro, Nancy G.J. Delaet, Eric Erb, Justin T. Ernst, Andrew Gibbs, Jeffrey Kahl, Linda Kessler, Jan Lundström, Stephen Miller, Hiroshi Nakanishi,