| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376786 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
A highly practicable synthesis of both enantiomers of 3-hydroxypipecolic acid derivatives 1, 2, 3, 4 is described. Screening of these molecules for glycosidase inhibition has been examined. Compound 3 was shown to be a potent inhibitor of β-N-acetylglucosaminidase as well as Escherichia coli β-glucuronidase.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chiaki Ohara, Ryouko Takahashi, Tatsunori Miyagawa, Yuichi Yoshimura, Atsushi Kato, Isao Adachi, Hiroki Takahata,