Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376789 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
The structure-activity relationship of the O-benzyl serine side chain was investigated based on the tetrazole-based growth hormone secretagogue BMS-317180 (2). The ortho position of the benzyl moiety was found to be favorable for introduction of substituents. A series of ortho-substituted compounds were synthesized with improved in-vitro and in-vivo activity. Among them, the biphenyl compound 2p shows twofold improvement in potency compared to its parent compound BMS-317180 (2).
Related Topics
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Authors
Jun Li, Stephanie Y. Chen, Shiwei Tao, Haixia Wang, James J. Li, Steve Swartz, Christa Musial, Andres A. Hernandez, Neil Flynn, Brian J. Murphy, Blake Beehler, Kenneth E. Dickinson, Leah Giupponi, Gary Grover, Ramakrishna Seethala, Paul Sleph,