| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376792 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure–activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for selected compounds are provided.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefan Peukert, Yingchuan Sun, Rui Zhang, Brian Hurley, Mike Sabio, Xiaoyu Shen, Christen Gray, JoAnn Dzink-Fox, Jianshi Tao, Regina Cebula, Sompong Wattanasin,