Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376802 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Protein prenyl transferases have been a focus of anti-cancer drug discovery in recent years due to their roles in post-translational modification of small GTP binding proteins. Attention is now turning to the development of GGTase I inhibitors. Here, we present the synthesis and biological evaluation of four GGPP analogs versus mammalian GGTase I and the discovery that 7-allyl GGPP is a surprisingly efficient GGTase I substrate.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michelle Maynor, Sarah A. Scott, Emily L. Rickert, Richard A. Gibbs,