| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376810 | Bioorganic & Medicinal Chemistry Letters | 2008 | 8 Pages |
Abstract
Based on 3-phenylpropionamides, a series of 3-arylpyrrolidine-2-carboxamide derivatives was designed and synthesized to study the effect of cyclizations as melanocortin-4 receptor ligands. It was found that the 2R,3R-pyrrolidine isomer possessed the most potent affinity among the four stereoisomers.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Joe A. Tran, Fabio C. Tucci, Melissa Arellano, Wanlong Jiang, Caroline W. Chen, Dragan Marinkovic, Beth A. Fleck, Jenny Wen, Alan C. Foster, Chen Chen,