Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376824 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
Introduction of polar groups in a series of potent CCR5 antagonists which are very likely to adversely affect the conduction system in the heart led to the identification of NIBR-1282 which did not show adverse effects when tested in an isolated rabbit heart ex vivo model. Administration of NIBR-1282 in combination with a non-efficacious dose of CsA led to significant prolongation of kidney allograft survival in cynomolgus monkeys.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gebhard Thoma, Christian Beerli, Marc Bigaud, Christian Bruns, Nigel G. Cooke, Markus B. Streiff, Hans-Guenter Zerwes,