| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376827 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Diaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition, such as azetidine derivative 3a, and broad spectrum anticoccidial activities in feed, such as morpholine derivative 8c, have been achieved.
Graphical abstractDiaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition and broad spectrum anticoccidial activities in feed have been achieved.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gui-Bai Liang, Xiaoxia Qian, Dennis Feng, Michael Fisher, Tami Crumley, Sandra J. Darkin-Rattray, Paula M. Dulski, Anne Gurnett, Penny Sue Leavitt, Paul A. Liberator, Andrew S. Misura, Samantha Samaras, Tamas Tamas, Dennis M. Schmatz, Matthew Wyvratt,