| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376836 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
1H-Tetrazole-1-alkanenitrile SR-9g exhibits a >10-fold in vivo potency enhancement over the lead nitrile 1 and has acceptable oral bioavailability in rats and dogs. An enantiospecific synthesis of 1H-tetrazole-1-alkanenitrile nitriles 9 has been developed.
Graphical abstractThe 1H-tetrazole-1-alkanenitrile SR-9g exhibits a >10-fold in vivo potency enhancement over the lead nitrile 1 and has acceptable oral bioavailability in rats and dogs. An enantiospecific synthesis of 1H-tetrazole-1-alkanenitrile nitriles 9 has been developed.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrés S. Hernández, Stephen G. Swartz, Dorothy Slusarchyk, Mujing Yan, R. Krishna Seethala, Paul Sleph, Gary Grover, Kenneth Dickinson, Leah Giupponi, Timothy W. Harper, W. Griffith Humphreys, Daniel A. Longhi, Neil Flynn, Brian J. Murphy,