| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376844 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Efforts to improve the properties of the well studied ketooxazole FAAH inhibitor OL-135 resulted in the discovery of a novel propylpiperidine series of FAAH inhibitors that has a modular design and superior properties to OL-135. The efficacy of one of these compounds was demonstrated in a rat spinal nerve ligation model of neuropathic pain in rats.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Amy Timmons, Mark Seierstad, Rich Apodaca, Matt Epperson, Dan Pippel, Sean Brown, Leon Chang, Brian Scott, Michael Webb, Sandra R. Chaplan, J. Guy Breitenbucher,