Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376856 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC50 values: 0.47, 11.2, 136.5 μM, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-κB through the inhibition of LPS-induced I-κB-α degradation in microglia.
Graphical abstractThree sesquiterpenoids from Xanthium strumarium (1, 2 and 3) inhibited the production of NO (IC50 = 0.47, 11.2, 136.5 μM, respectively), expression of iNOS/COX-2 and degradation of I-κB-α in activated microglia.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Jeong Hoon Yoon, Hyo Jin Lim, Hwa Jin Lee, Hee-Doo Kim, Raok Jeon, Jae-Ha Ryu,