| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376859 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
This letter shows inhibitor SAR on a pyridine series of allosteric Akt inhibitors to optimize enzymatic and cellular potency. We have optimized 2,3,5-trisubstituted pyridines to give potent Akt1 and Akt2 inhibitors in both enzyme and cell based assays. In addition, we will also highlight the pharmacokinetic profile of an optimized inhibitor that has low clearance and long half-life in dogs.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John C. Hartnett, Stanley F. Barnett, Mark T. Bilodeau, Deborah Defeo-Jones, George D. Hartman, Hans E. Huber, Raymond E. Jones, Astrid M. Kral, Ronald G. Robinson, Zhicai Wu,