| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376863 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
This paper describes the rapid assembly of four different classes of potent Akt inhibitors from a common intermediate. Among them, a pyridopyrimidine series displayed the best intrinsic and cell potency against Akt1 and Akt2. This series also showed a promising pharmacokinetic profile and excellent selectivity over other closely related kinases.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhicai Wu, Ronald G. Robinson, Sheng Fu, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, Astrid M. Kral, Hans E. Huber, Nancy E. Kohl, George D. Hartman, Mark T. Bilodeau,