| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376875 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups, producing highly potent inhibitors with encouraging oral pharmacokinetic profiles and significant but sub-optimal anticoagulant activities.
Graphical abstractStructure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating biaryl P4 groups, producing highly potent inhibitors with encouraging oral pharmacokinetic profiles and significant but sub-optimal anticoagulant activities.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Robert J. Young, Alan D. Borthwick, David Brown, Cynthia L. Burns-Kurtis, Matthew Campbell, Chuen Chan, Marie Charbaut, Chun-wa Chung, Máire A. Convery, Henry A. Kelly, N. Paul King, Savvas Kleanthous, Andrew M. Mason, Anthony J. Pateman,