Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376877 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Ongoing clinical studies indicate that inhibitors of Class I and Class II histone deacetylase (HDAC) enzymes show great promise for the treatment of cancer. Zolinza® (SAHA, Zolinza®) was recently approved by the FDA for the treatment of the cutaneous manifestations of cutaneous T-cell lymphoma. As a part of an ongoing effort to identify novel small molecules to target these important enzymes, we have prepared several classes of amino acid-derived HDAC1 inhibitors. The design rationale and in vitro activity against the HDAC1 enzyme and HCT116 cell line are described in this letter.
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Authors
Jed L. Hubbs, Hua Zhou, Astrid M. Kral, Judith C. Fleming, William K. Dahlberg, Bethany L. Hughes, Richard E. Middleton, Alexander A. Szewczak, J. Paul Secrist, Thomas A. Miller,