| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376880 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
This letter describes the development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved aqueous solubility (∼18 mg/mL) that translates into enhanced cell activity and caspase-3 induction.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhijian Zhao, Ronald G. Robinson, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, George D. Hartman, Hans E. Huber, Mark E. Duggan, Craig W. Lindsley,