| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376881 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
A series of potent and binding selective LXRβ agonists was developed using the previously reported non-selective LXR ligand WAY-254011 as a structural template. With the aid of molecular modeling, it was found that 2,3-diMe-Ph, 2,5-diMe-Ph, and naphthalene substituted quinoline acetic acids (such as quinoline 33, 37, and 38) showed selectivity for LXRβ over LXRα in binding assays.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Baihua Hu, Elaine Quinet, Rayomand Unwalla, Mike Collini, James Jetter, Rebecca Dooley, Diane Andraka, Lisa Nogle, Dawn Savio, Anita Halpern, Annika Goos-Nilsson, Anna Wilhelmsson, Ponnal Nambi, Jay Wrobel,