| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376883 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
The structure-based design and synthesis of isothiazolidinone (IZD) inhibitors of PTP1B containing imidazoles and imidazolines and their modification to interact with the B site of PTP1B are described here. The X-ray crystal structures of 3I and 4I complexed with PTP1B were solved and revealed the inhibitors are interacting extensively with the B site of the enzyme.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Brent Douty, Brian Wayland, Paul J. Ala, Michael J. Bower, James Pruitt, Lori Bostrom, Min Wei, Ronald Klabe, Lucie Gonneville, Richard Wynn, Timothy C. Burn, Phillip C.C. Liu, Andrew P. Combs, Eddy W. Yue,