| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376887 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Optimisation of a series of oxazole diketopiperazines has led to the discovery of a very potent and selective oxytocin antagonist GSK221149A. GSK221149A has been shown to inhibit oxytocin-induced uterine contractions in the anaesthetised rat.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
John Liddle, Michael J. Allen, Alan D. Borthwick, David P. Brooks, David E. Davies, Richard M. Edwards, Anne M. Exall, Chris Hamlett, Wendy R. Irving, Andrew M. Mason, Gerald P. McCafferty, Fabrizio Nerozzi, Simon Peace, Joanne Philp, Derek Pollard,