The expedient synthesis of 1,5-benzothiazepines as a family of cytotoxic drugs

The expedient synthesis of 1,5-benzothiazepines using LaY zeolite under stirring condition is reported and synthesized compound screened for cytotoxic activity. The reaction produces the product in relatively low yields and requires a long time when they were performed in various solvents under conventional and microwave irradiation. Thus, the procedure provides a simple and green synthetic methodology under environmentally friendly conditions.

Graphical abstractThe expedient synthesis of 1,5-benzothizeopines using LaY zeolite under stirring condition is reported and synthesized compound screened for cytotoxic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide