| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376900 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
In an effort to obtain a MMP selective and potent inhibitor of HER-2 sheddase (ADAM-10), the P1′ group of a novel class of (6S,7S)-7-[(hydroxyamino)carbonyl]-6-carboxamide-5-azaspiro[2.5]octane-5-carboxylates was attenuated and the structure–activity relationships (SAR) will be discussed. In addition, it was discovered that unconventional perturbation of the P2′ moiety could confer MMP selectivity, which was hypothesized to be a manifestation of the P2′ group effecting global conformational changes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wenqing Yao, Jincong Zhuo, David M. Burns, Yun-Long Li, Ding-Quan Qian, Colin Zhang, Chunhong He, Meizhong Xu, Eric Shi, Yanlong Li, Cindy A. Marando, Maryanne B. Covington, Gengjie Yang, Xiangdong Liu, Max Pan, Jordan S. Fridman, Peggy Scherle,