Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretase

The synthesis and γ-secretase inhibition data for a series of nitrogen-appended N-alkylsulfonamides (11–47) are described. Inhibition of brain Aβ in transgenic mice was demonstrated by two of these compounds (23 and 44).

Graphical abstractStructure–activity relationships of nitrogen-appended N-alkylsulfonamide γ-secretase inhibitors are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide