| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376917 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
β-Benzamido hydroxamic acids were discovered as potent TACE inhibitors. A computer model was constructed to help understanding the binding activities and guiding SAR study. SAR optimization led to the discovery of compound 30 which met all in vitro and in vivo criteria for the program and was selected for further evaluation.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James J.-W. Duan, Lihua Chen, Zhonghui Lu, Chu-Biao Xue, Rui-Qin Liu, Maryanne B. Covington, Mingxin Qian, Zelda R. Wasserman, Krishna Vaddi, David D. Christ, James M. Trzaskos, Robert C. Newton, Carl P. Decicco,