| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376920 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
The optimisation of affinity and selectivity in a novel series of dual 5-HT5A/5-HT7 receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines with low nanomolar affinities were identified.
Graphical abstractThe optimisation of affinity and selectivity in a novel series of dual 5-HT5A/5-HT7 receptor ligands is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Jens-Uwe Peters, Thomas Lübbers, Alexander Alanine, Sabine Kolczewski, Francesca Blasco, Lucinda Steward,