| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376929 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
A novel series of bis(pyrrol-2-yl-methyleneamine) ligands H2Ln (n = 1–4) were synthesized via condensation of diamines with two equivalents of 2-formyl-pyrrole (2). Their Zn(II) complexes were characterized by elemental analyses, mass spectra and IR spectra. The crystal structures of [ZnL1]2 and [ZnL4]2 obtained from ethanol solution was determined by X-ray diffraction analysis, each of them possesses a double-stranded helical geometry. In addition, the DNA-binding properties of the compounds have been fully investigated by absorption, fluorescence and viscosity measurements.
Graphical abstractA novel series of bis(pyrrol-2-yl-methyleneamine) ligands H2Ln and their Zn(II) complexes were synthesized. The crystal structures of [ZnL1]2 and [ZnL4]2 show that each of them possesses a double-stranded helical geometry. In addition, the DNA-binding properties of the compounds have been fully investigated.Figure optionsDownload full-size imageDownload as PowerPoint slide
