| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376931 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase. Furthermore, carbamate 4d was able to revert the amnesic effects of scopolamine in the passive avoidance test in rats.
Graphical abstractThe synthesis and biological evaluation of 4-aminopyridine derivatives with anticholinesterase and antiamnesic activity is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Luigi Scipione, Daniela De Vita, Alessandra Musella, Lisa Flammini, Simona Bertoni, Elisabetta Barocelli,