Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

Graphical abstractThe biphenyl amides (BPAs) are a novel series of p38α MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.Figure optionsDownload full-size imageDownload as PowerPoint slide