Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376935 | Bioorganic & Medicinal Chemistry Letters | 2008 | 7 Pages |
Abstract
We describe here a series of N-(quinolin-8-yl)benzenesulfonamides capable of suppressing the NFκB pathway identified from two high-throughput screens run at two centers of the NIH Molecular Libraries Initiative. These small molecules were confirmed in both primary and secondary assays of NFκB activation and expanded upon through analogue synthesis. The series exhibited potencies in the cell-based assays at as low as 0.6 μM, and several indications suggest that the targeted activity lies within a common region of the NFκB pathway.
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Related Topics
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Organic Chemistry
Authors
Yuli Xie, ShiXian Deng, Craig J. Thomas, Yidong Liu, Ya-Qin Zhang, Alison Rinderspacher, Wenwei Huang, Gangli Gong, Michael Wyler, Efithia Cayanis, Nathalie Aulner, Udo Többen, Caty Chung, Sergey Pampou, Noel Southall, Dušica Vidović, Stephan Schürer,