| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376939 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
Structure–activity relationships (SAR) were analyzed within a library of diverse yet simple compounds prepared as histamine H3 antagonists. The libraries were constructed with a variety of low molecular weight pyrrolidines, selected from (R)-2-methylpyrrolidine, (S)-2-methylpyrrolidine, and pyrrolidine.
Graphical abstractThe SAR of a 60-compound library of H3 antagonists comprising 20 different core moieties each incorporating pyrrolidine, (R)-2-methylpyrrolidine, and (S)-2-methylpyrrolidine is discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Diana L. Nersesian, Lawrence A. Black, Thomas R. Miller, Timothy A. Vortherms, Timothy A. Esbenshade, Arthur A. Hancock, Marlon D. Cowart,