| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376940 | Bioorganic & Medicinal Chemistry Letters | 2008 | 6 Pages |
Abstract
Tetrapyrrole ethanolamide derivatives, 1 and 2, were prepared from hematoporphyrin IX (HPIX, 3) and methyl pheophorbide a (mPheo, 6). These were evaluated for their dual action as chemotherapeutics and photosensitizers in treatment of cancer. The novel compounds showed significant in vitro anticancer activity as measured in different cell lines using the MTT assay and photodynamic activity measured by erythrocytes’ photohemolysis.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Denis Girard, Glenn Weagle, Atul Gupta, Gervais Bérubé, Camille Chapados,