| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376942 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The compound named Histidine–pyridine–histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their antiviral activities against herpes simplex virus type 1. HPH-8 showed potent antiviral activity with an EC50 of 15 μM, and relatively high cytotoxicity with a CC50 of 37 μM. In contrast, HPH-4 indicated a weaker antiviral activity with an EC50 of 79 μM, but exhibited a far more less cytotoxicity (CC50 500 μM). Other HPH derivatives showed no effects against antiviral activities and cytotoxicities.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tetsuji Hosono, Kazumi Yokomizo, Akiyuki Hamasaki, Yoshinari Okamoto, Tadashi Okawara, Masami Otsuka, Ryozaburo Mukai, Keitarou Suzuki,