| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376946 | Bioorganic & Medicinal Chemistry Letters | 2008 | 5 Pages |
Abstract
A series of small molecule STAT3 inhibitors originally derived from our lead compound STA 21 were synthesized and evaluated. The most potent compound in this series, compound 1, exhibited the same anti-proliferative activities as STA 21 against prostate cancer cell lines that express constitutively active STAT3. Molecular docking showed compound 1 bound to the STAT3β SH2 domain in a similar manner as STA 21.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Deepak Bhasin, Katryna Cisek, Trupti Pandharkar, Nicholas Regan, Chenglong Li, Bulbul Pandit, Jiayuh Lin, Pui-Kai Li,