Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1376953 | Bioorganic & Medicinal Chemistry Letters | 2008 | 4 Pages |
Abstract
The complex etiology of Alzheimer’s disease (AD) prompts scientists to develop multifunctional compounds to combat causes and symptoms of such neurodegeneration. To this aim we designed, synthesized, and tested a series of compounds by introducing halophenylalkylamidic functions on the scaffold of AP2238, which is a dual binding site acetylcholinesterase inhibitor. The inhibitory activity was successfully extended to the beta-site amyloid precursor protein cleavage enzyme, leading to the discovery of a potent inhibitor of this enzyme (3) and affording multifunctional compounds (2, 6, 8) for the treatment of AD.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lorna Piazzi, Andrea Cavalli, Francesco Colizzi, Federica Belluti, Manuela Bartolini, Francesca Mancini, Maurizio Recanatini, Vincenza Andrisano, Angela Rampa,