Diaryl substituted pyrrolidinones and pyrrolones as 5-HT2C inhibitors: Synthesis and biological evaluation

Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT2C receptor antagonists and the discovery of a new class of potent and selective 5-HT2C molecules are reported.

Graphical abstractThe synthesis of a new class of potent and selective 5-HT2C antagonists (7) is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide