| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1376970 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
Synthesis and biological evaluation of possible prodrugs of COX-2 inhibitors involving sulfonamide and hydroxymethyl groups of 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamides are described. Out of many options, the sodium salt of N-propionyl sulfonamide demonstrated much improved pharmacological profiles and physicochemical properties suitable for oral as well as parenteral administration.
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Related Topics
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Authors
Sunil Kumar Singh, Saibaba Vobbalareddy, Srinivasa Rao Kalleda, Seshagiri Rao Casturi, Ramesh Mullangi, Rajagopalan Ramanujam, Koteswar Rao Yeleswarapu, Javed Iqbal,